{"id":547,"date":"2024-04-12T20:45:54","date_gmt":"2024-04-12T12:45:54","guid":{"rendered":"https:\/\/blog.ineuro.net\/?p=547"},"modified":"2024-04-12T20:45:56","modified_gmt":"2024-04-12T12:45:56","slug":"%e5%b0%8f%e9%bc%a0%e4%b8%ad%e6%9e%a2%e7%a5%9e%e7%bb%8f%e7%b3%bb%e7%bb%9f%e8%84%b1%e9%ab%93%e9%9e%98%e5%92%8c%e5%86%8d%e9%ab%93%e9%9e%98%e8%84%91%e7%bb%86%e8%83%9e%e8%bd%ac%e5%bd%95%e7%bb%84%e5%9b%be","status":"publish","type":"post","link":"https:\/\/blog.ineuro.net\/index.php\/2024\/04\/12\/547\/","title":{"rendered":"\u5c0f\u9f20\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u8131\u9ad3\u9798\u548c\u518d\u9ad3\u9798\u8111\u7ec6\u80de\u8f6c\u5f55\u7ec4\u56fe\u8c31\u548c\u76f8\u4e92\u4f5c\u7528\u7f51\u7edc"},"content":{"rendered":"\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>code:https:\/\/github.com\/marcocolonnalab\/CPZ<\/p>\n<cite>\u539f\u6587\u5730\u5740\uff1a<a 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class=\"wp-block-image\"><img alt=\"\u56fe\u7247[2]-\u5403\u4e86\u5403\u4e86\" decoding=\"async\" src=\"https:\/\/cdn.ineuro.net\/cloudreve%2F2024%2F04%2F11%2F4JSnfyyn_1.s2.png\" 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class=\"wp-block-image\"><img alt=\"\u56fe\u7247[7]-\u5403\u4e86\u5403\u4e86\" decoding=\"async\" src=\"https:\/\/cdn.ineuro.net\/cloudreve%2F2024%2F04%2F12%2F47IfEQFy_1.4.png\" \/><\/figure>\n\n\n\n<p>\u56fe4<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img alt=\"\u56fe\u7247[8]-\u5403\u4e86\u5403\u4e86\" decoding=\"async\" src=\"https:\/\/cdn.ineuro.net\/cloudreve%2F2024%2F04%2F12%2F8s8qnXvU_1.S5.png\" \/><\/figure>\n\n\n\n<p>\u56fes5<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u9ad3\u9798\u518d\u751f\u4e0e\u8840\u7ba1\u7ec6\u80de\u91cd\u7f16\u7a0b\u76f8\u5173<\/h2>\n\n\n\n<p>\u9664\u4e86\u80f6\u8d28\u7ec6\u80de\uff0cCPZ\u6cbb\u7597\u8fd8\u8bf1\u5bfc\u4e86\u8840\u7ba1\u548c\u95f4\u8d28\u8111\u7ec6\u80de\u7fa4\u7684\u7279\u5f81\u6027\u6539\u53d8\u3002<br>\u5bf9\u8fd9\u4e9b\u7ec6\u80de\u95f4\u5ba4\u7684DEGs\u8fdb\u884c\u5206\u6790\uff0c\u53d1\u73b0\u9ad3\u9798\u518d\u751f\u4e0e\u8131\u9ad3\u9798\u671f\u95f4\u53d1\u751f\u4e86\u663e\u8457\u53d8\u5316(\u56feS6A\u548cS6B)\u3002\u5bf9\u8fd9\u4e9bDEGs\u8fdb\u884c\u7684\u901a\u8def\u5206\u6790\u7a81\u51fa\u4e86\u7ec4\u7ec7\u53d1\u80b2\u3001\u7ec6\u80de\u9ecf\u9644\u548c\u8fc1\u79fb\u901a\u8def(\u56feS6C)\u3002\u6211\u4eec\u8fdb\u4e00\u6b65\u5c06\u8840\u7ba1\u95f4\u8d28\u7ec6\u80de\u5206\u4e3a\u5185\u76ae\u7ec6\u80de(Endo.1\u548cEndo.2)\uff0c\u5468\u7ec6\u80de\uff0c\u5e73\u6ed1\u808c\u7ec6\u80de(SMCs)\uff0c\u8111\u819c\u6210\u7ea4\u7ef4\u7ec6\u80de(Fibro.1)\u548c\u8840\u7ba1\u5468\u56f4\u6210\u7ea4\u7ef4\u7ec6\u80de(Fibro.2-4)63,64(\u56fe5A\u548cS6D)\uff0c\u5e76\u68c0\u6d4b\u4e86DEGs\u7684\u8868\u8fbe(\u56fe5B)\u3002\u8840\u7ba1\u5468\u56f4\u6210\u7ea4\u7ef4\u7ec6\u80de(Fibro.4)\u548c\u5468\u7ec6\u80de\u4e0a\u8c03\u4e86\u8840\u7ba1\u751f\u6210\u6807\u5fd7\u7269Cd248\u300265\u5468\u7ec6\u80de\u653e\u5927\u4e86CSF1R\u914d\u4f53Il34\u7684\u8868\u8fbe\uff0c\u8be5\u914d\u4f53\u53ef\u80fd\u5728\u8840\u7ba1\u91cd\u5851\u671f\u95f4\u7ef4\u6301\u8840\u7ba1\u5468\u56f4\u5de8\u566c\u7ec6\u80de\u3002\u6210\u7ea4\u7ef4\u7ec6\u80de\u9ad8\u8868\u8fbeLoxl2\uff0c\u8be5\u57fa\u56e0\u7f16\u7801\u4e00\u79cd\u7f3a\u6c27\u8bf1\u5bfc\u7684\u80fa\u6c27\u5316\u9176\uff0c\u901a\u8fc7\u50ac\u5316\u80f6\u539f\u548c\u5f39\u6027\u86cb\u767d\u7684\u4ea4\u8054\u6765\u4fc3\u8fdbECM\u91cd\u5851\u3002SMCs\u4e0a\u8c03Pdlim5\uff0c\u8fd9\u4fc3\u8fdb\u4e86\u7f3a\u6c27\u4ecb\u5bfc\u7684\u8840\u7ba1\u91cd\u585168(\u56fe5B)\u3002<br>\u6211\u4eec\u68c0\u6d4b\u4e86\u6574\u4e2aCPZ\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u8840\u7ba1\u4e9a\u7c07\u7684\u76f8\u5bf9\u4e30\u5ea6\uff1a\u5468\u7ec6\u80de\u6709\u4e0b\u964d\u8d8b\u52bf\uff0c\u800c\u5728\u8131\u9ad3\u9798\u8fc7\u7a0b\u4e2dEndo.2\u6269\u589e(\u56feS6E)\u3002\u5468\u7ec6\u80de\u7684\u4e27\u5931\u53ef\u80fd\u5bfc\u81f4\u8840\u8111\u5c4f\u969c\u901a\u900f\u6027\u589e\u52a0\u3002\u4e0eEndo.1\u76f8\u6bd4\uff0cEndo.2\u7c07\u8868\u8fbe\u7f3a\u6c27\u8bf1\u5bfc\u7684\u57fa\u56e0Rgs5,71\u4ee5\u53ca\u6c27\u5316\u5e94\u6fc0\u548cIFN\u66b4\u9732\u7684\u6807\u5fd7\u7269(\u56fe5C\u548c5D)\u3002\u6709\u8da3\u7684\u662f\uff0c\u5728\u9ad3\u9798\u518d\u751f\u8fc7\u7a0b\u4e2d\uff0c\u8840\u7ba1\u5468\u6210\u7ea4\u7ef4\u7ec6\u80de(Fibro.2)\u4e0a\u8c03\u4e86\u5f71\u54cd\u5185\u76ae\u751f\u7269\u5b66\u7684\u57fa\u56e0(\u56feS6F)\uff1a\u4f8b\u5982\uff0c\u4fc3\u8fdb\u5185\u76ae\u7ec6\u80de\u8840\u7ba1\u751f\u6210\u6d3b\u6027\u7684Ccn172\u548c\u4fc3\u8fdb\u5185\u76ae\u7ec6\u80de\u51cb\u4ea1\u7684Timp373\u3002\u603b\u4e4b\uff0c\u8fd9\u4e9b\u7ed3\u679c\u8bc1\u660e\u4e86\u8840\u7ba1\u7ec6\u80de\u5bf9\u7f3a\u6c27\u548c\u8840\u7ba1\u635f\u4f24\u7684\u53cd\u5e94\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img alt=\"\u56fe\u7247[9]-\u5403\u4e86\u5403\u4e86\" decoding=\"async\" src=\"https:\/\/cdn.ineuro.net\/cloudreve%2F2024%2F04%2F12%2FQzyRdcUP_1.5.png\" \/><\/figure>\n\n\n\n<p>\u56fe5<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img alt=\"\u56fe\u7247[10]-\u5403\u4e86\u5403\u4e86\" decoding=\"async\" src=\"https:\/\/cdn.ineuro.net\/cloudreve%2F2024%2F04%2F12%2FjZmp9nxO_1.s6.png\" \/><\/figure>\n\n\n\n<p>\u56fes6<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u8f6c\u5f55\u53d8\u5316\u4ec5\u90e8\u5206\u53cd\u6620\u795e\u7ecf\u5143\u529f\u80fd\u7f3a\u9677<\/h2>\n\n\n\n<p>\u5bf9\u795e\u7ecf\u5143\u7684snRNA-seq\u5206\u6790\u663e\u793a\uff0c\u9ad3\u9798\u518d\u751f\u540e\u795e\u7ecf\u5143\u6838\u7684\u6bd4\u4f8b\u7565\u6709\u964d\u4f4e(\u56fe1D)\uff0c\u8fd9\u53ef\u80fd\u662f\u8131\u9ad3\u9798\u540e\u8f74\u7a81\u53d8\u6027\u5ef6\u8fdf\u7684\u7ed3\u679c\u3002\u5bf9\u795e\u7ecf\u5143\u4e9a\u7c07\u7684DEGs\u5206\u6790\u663e\u793a\uff0c\u9ad3\u9798\u518d\u751f\u4e0e\u53c2\u4e0e\u795e\u7ecf\u53d1\u751f\u7684\u57fa\u56e0\u4e0a\u8c03\u76f8\u5173\uff0c\u63d0\u793a\u8bd5\u56fe\u8865\u507f\u795e\u7ecf\u5143\u635f\u4f24(\u56feS7A\u548cS7B)\u3002\u795e\u7ecf\u5143\u4e2d\u8868\u8fbe\u589e\u52a0\u6700\u591a\u7684\u57fa\u56e0\u4e4b\u4e00\u662fEpha5\uff0c\u7f16\u7801\u53c2\u4e0e\u795e\u7ecf\u5143\u7a81\u89e6\u5f62\u6210\u7684Eph\u53d7\u4f5374\u3002\u8fd9\u4e9b\u9002\u5ea6\u7684\u8f6c\u5f55\u53d8\u5316\u4e0e\u5148\u524d\u62a5\u9053\u7684CPZ\u8bf1\u5bfc\u7684\u8131\u9ad3\u9798\u4e2d\u663e\u8457\u964d\u4f4e\u7684\u795e\u7ecf\u5143\u6d3b\u6027\u5f62\u6210\u5bf9\u6bd475\u3002\u6b64\u5916\uff0c\u5bf9CPZ\u6cbb\u7597\u5c0f\u9f20\u8fdb\u884c\u7a81\u89e6\u524d\u6807\u5fd7\u7269\u7a81\u89e6\u7d20\u7684\u514d\u75ab\u67d3\u8272\u8bc1\u5b9e\u4e86\u8131\u9ad3\u9798\u548c\u9ad3\u9798\u518d\u751f\u671f\u95f4\u7a81\u89e6\u51cf\u5c11(\u56feS7C)\u3002\u6211\u4eec\u5f97\u51fa\u7ed3\u8bba\uff0c\u8f6c\u5f55\u53d8\u5316\u4ec5\u90e8\u5206\u53cd\u6620\u4e86CPZ\u8bf1\u5bfc\u7684\u795e\u7ecf\u5143\u7f3a\u9677\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img alt=\"\u56fe\u7247[11]-\u5403\u4e86\u5403\u4e86\" decoding=\"async\" src=\"https:\/\/cdn.ineuro.net\/cloudreve%2F2024%2F04%2F12%2FR1TqeSos_1.s7.png\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">snRNA-seq\u63ed\u793a\u8131\u9ad3\u9798\u8bf1\u53d1\u7684\u7ec6\u80de-\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528<\/h2>\n\n\n\n<p>\u5229\u7528snRNA-seq\u63d0\u4f9b\u7684\u5168\u9762\u8f6c\u5f55\u7ec4\u4fe1\u606f\uff0c\u6211\u4eec\u5229\u7528NicheNet\u5206\u6790\u63a2\u7d22\u4e86\u6240\u6709\u8111\u7ec6\u80de\u7c7b\u578b\u4e4b\u95f4\u7684\u6f5c\u5728\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\uff0cNicheNet\u5206\u6790\u9884\u6d4b\u53d1\u9001\u7ec6\u80de\u4e2d\u7684\u54ea\u4e9b\u914d\u4f53\u53ef\u80fd\u8c03\u8282\u63a5\u6536\u7ec6\u80de\u4e2d\u7684\u57fa\u56e0\u8868\u8fbe\u53d8\u5316\u300276\u5177\u4f53\u800c\u8a00\uff0c\u6211\u4eec\u5229\u7528NicheNet\u5bf9\u914d\u4f53-\u53d7\u4f53\u5bf9\u8fdb\u884c\u6392\u5e8f\uff0c\u8fd9\u4e9b\u914d\u4f53-\u53d7\u4f53\u5bf9\u6700\u6709\u53ef\u80fd\u89e3\u91ca\u8131\u9ad3\u9798\u671f\u95f4\u63a5\u6536\u7ec6\u80de\u4e0e\u6b63\u5e38\u60c5\u51b5\u4e0b\u7684\u5dee\u5f02\u57fa\u56e0\u8868\u8fbe(\u56fe6A-6C)\uff0c\u5e76\u5c06\u8fd9\u4e9b\u914d\u4f53\u548c\u53d7\u4f53\u7684\u57fa\u56e0\u8868\u8fbe\u6620\u5c04\u5230\u5404\u79cd\u7ec6\u80de\u7c7b\u578b(\u56feS7D\u548cS7E)\u3002\u5176\u4e2d\u4e00\u4e2a\u9876\u7ea7\u914d\u4f53\u662f\u795e\u7ecf\u5143\/\u795e\u7ecf\u80f6\u8d28\u884d\u751f\u7684\u795e\u7ecf\u8ff7\u79bb\u86cb\u767d(NFASC)\uff0c\u9884\u6d4b\u4f1a\u4e0e\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u7cfb\u7ec6\u80de\u4e2d\u8868\u8fbe\u7684Contactin1(CNTN1)\u7ed3\u5408(\u56fe6A,6B,S7D\u548cS7E)\u3002\u795e\u7ecf\u80f6\u8d28\u548c\u8f74\u7a81\u4e4b\u95f4\u7684NFASC-CNTN1\u76f8\u4e92\u4f5c\u7528\u5f71\u54cd\u8f74\u7a81-\u80f6\u8d28\u8fde\u63a5\u5f62\u6210\u3001\u9ad3\u9798\u7ef4\u62a4\u548c\u8f74\u7a81\u5206\u79bb\u300277,78 NFASCCNTN1\u76f8\u4e92\u4f5c\u7528\u8fd8\u8bf1\u5bfcOPCs\u5206\u5316\u4e3a\u6210\u719f\u7684\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\uff0c\u4fc3\u8fdb\u795e\u7ecf\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u7684\u9ad3\u9798\u5f62\u6210\u300279\u56e0\u6b64\uff0c\u8131\u9ad3\u9798\u671f\u95f4NFASC-CNTN1\u76f8\u4e92\u4f5c\u7528\u5bf9\u795e\u7ecf\u53d1\u80b2\u548c\u795e\u7ecf\u53d1\u80b2\u7684\u795e\u7ecf\u53d1\u80b2\u548c\u795e\u7ecf\u53d1\u80b2\u7684\u795e\u7ecf\u53d1\u80b2\u6709\u91cd\u8981\u610f\u4e49\u3002CPZ\u6cbb\u7597\u53ef\u80fd\u5f3a\u8c03\u4e86\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u5206\u5316\u7684\u8fc7\u7a0b\uff0c\u7c7b\u4f3c\u4e8e\u51fa\u751f\u540e\u5927\u8111\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u53d1\u751f\u7684\u8fc7\u7a0b\u3002<br>Nichenet\u5206\u6790\u8fd8\u663e\u793a\uff0c\u5c0f\u80f6\u8d28\u7ec6\u80de\u8868\u8fbe\u7684\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b5013(FGF13)\u53ef\u80fd\u901a\u8fc7\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u53d7\u4f533(FGFR3)\u523a\u6fc0\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u3002\u6b64\u5916\uff0c\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u548c\u5c0f\u80f6\u8d28\u7ec6\u80de\u8868\u8fbe\u7684SEMA4D\u53ef\u80fd\u901a\u8fc7\u4e0ePlexinb1(PLXNB1)\u76f8\u4e92\u4f5c\u7528\u5f71\u54cd\u661f\u5f62\u80f6\u8d28\u7ec6\u80de(\u56fe6B\u3001S7D\u548cS7E)\u3002PLXNB1\u4e0eAD\u60a3\u8005\u7684\u8ba4\u77e5\u4e0b\u964d\u76f8\u5173\uff0c\u661f\u5f62\u80f6\u8d28\u7ec6\u80dePLXNB1\u7684\u6572\u4f4e\u5bfc\u81f4\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u57f9\u517b\u7269\u4e2d\u7ec6\u80de\u5916Ab42\u6c34\u5e73\u964d\u4f4e80\u3002\u6b64\u5916\uff0c\u5c0f\u80f6\u8d28\u7ec6\u80de-\u661f\u5f62\u80f6\u8d28\u7ec6\u80deSEMA4D-PLXNB1\u76f8\u4e92\u4f5c\u7528\u52a0\u5267\u4e86EAE\u671f\u95f4\u7684\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u708e\u75c781\u3002\u540c\u6837\uff0cSEMA4D\u53ef\u80fd\u901a\u8fc7\u4e0e\u661f\u5f62\u80f6\u8d28\u7ec6\u80dePLXNB1\u76f8\u4e92\u4f5c\u7528\u52a0\u5267CPZ\u6a21\u578b\u4e2d\u7684\u75c5\u7406\u3002<br>\u7531\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u4ea7\u751f\u7684\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50A(VEGFA)\u662f\u9884\u6d4b\u5728\u8131\u9ad3\u9798\u8fc7\u7a0b\u4e2d\u901a\u8fc7VEGFA\u5171\u53d7\u4f53\u795e\u7ecf\u7ea4\u6bdb\u86cb\u767d1\/2(NRP1\/2)\u5f71\u54cd\u5c0f\u80f6\u8d28\u7ec6\u80de\u57fa\u56e0\u8868\u8fbe\u53d8\u5316\u7684\u9876\u7ea7\u914d\u4f53\u4e4b\u4e0082(\u56fe6C\u3001S7D\u548cS7E)\u3002\u5c0f\u80f6\u8d28\u7ec6\u80deNRP1\u901a\u8fc7\u4e0eOPCs\u4e0a\u7684\u8840\u5c0f\u677f\u884d\u751f\u751f\u957f\u56e0\u5b50a(PDGFRa)\u76f8\u4e92\u4f5c\u7528\u4fc3\u8fdb\u9ad3\u9798\u518d\u751f83\u3002\u56e0\u6b64\uff0c\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u6765\u6e90\u7684VEGFA\u3001\u5c0f\u80f6\u8d28\u7ec6\u80deNRP1\u548cOPC PDGFRa\u53ef\u80fd\u951a\u5b9a\u63a7\u5236\u9ad3\u9798\u5f62\u6210\u7684\u7535\u8def\u3002<br>\u9664\u4e86\u4e0a\u8ff0\u76f8\u4e92\u4f5c\u7528\uff0c\u6211\u4eec\u8fd8\u8bc1\u5b9e\u4e86TAM\u53d7\u4f53\u4e0eGAS6\u548cPROS1\u7684\u76f8\u4e92\u4f5c\u7528\uff0cGAS6\u548cPROS1\u8bc6\u522b\u51cb\u4ea1\u7ec6\u80de\u8868\u9762\u7684\u78f7\u8102\u9170\u4e1d\u6c28\u9178\uff0c\u5e76\u5df2\u88ab\u8bc1\u660e\u5bf9\u9ad3\u9798\u5f62\u6210\u6709\u5f71\u54cd20,84,85\u3002\u6709\u8da3\u7684\u662f\uff0c\u6211\u4eec\u53d1\u73b0\u4e0d\u540c\u7684\u7ec6\u80de\u7c7b\u578b\u5229\u7528\u4e0d\u540c\u7684TAM\u53d7\u4f53\u7ed3\u5408GAS6\u548cPROS1\uff1a\u5c0f\u80f6\u8d28\u7ec6\u80de\u548c\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u8868\u8fbeAXL\u548cMERTK\uff0c\u800c\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u548c\u795e\u7ecf\u5143\u4e3b\u8981\u8868\u8fbeTYRO3(\u56fe6A-6C,S7D\u548cS7E)\u3002\u5728CPZ\u6a21\u578b\u4e2d\uff0c\u5c0f\u80f6\u8d28\u7ec6\u80de\u4e3b\u8981\u8868\u8fbePros1(\u56feS7D)\uff0c\u6211\u4eec\u5728\u57f9\u517b\u539f\u4ee3\u5c0f\u80f6\u8d28\u7ec6\u80de\u7684\u7ec6\u80de\u88c2\u89e3\u7269\u7684\u86cb\u767d\u6c34\u5e73\u9a8c\u8bc1\u4e86\u8fd9\u4e00\u70b9(\u56feS7F)\u3002\u4e3a\u4e86\u8fdb\u4e00\u6b65\u8bc1\u660ePROS1\u5bf9\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u6444\u53d6\u51cb\u4ea1\u7ec6\u80de\u7684\u5f71\u54cd\uff0c\u6211\u4eec\u7528\u7fa7\u57fa\u8367\u5149\u7d20\u7425\u73c0\u9170\u4e9a\u80fa\u916f(CFSE)\u6807\u8bb0\u7684\u51cb\u4ea1\u80f8\u817a\u7ec6\u80de\u4e0e\u542b\u6709\u6216\u4e0d\u542b\u6709\u5c0f\u9f20PROS1\u7684\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u5171\u57f9\u517b\uff0c\u5e76\u7528\u6d41\u5f0f\u7ec6\u80de\u672f\u8bc4\u4f30\u541e\u566c\u4f5c\u7528(\u56fe6D)\u3002<br>PROS1\u86cb\u767d\u589e\u5f3a\u4e86\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u5bf9\u51cb\u4ea1\u80f8\u817a\u7ec6\u80de\u7684\u541e\u566c\u4f5c\u7528(\u56fe6E-6G)\uff0c\u652f\u6301\u4e86TAM\u53d7\u4f53\u5728\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u541e\u566c\u51cb\u4ea1\u7ec6\u80de\u4e2d\u7684\u91cd\u8981\u6027\u3002\u5728CPZ\u6a21\u578b\u4e2d\uff0cPROS1-AXL\/MERTK\u76f8\u4e92\u4f5c\u7528\u5728\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u4ecb\u5bfc\u7684\u51cb\u4ea1\u7ec6\u80de\u6e05\u9664\u4e2d\u7684\u4f5c\u7528\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img alt=\"\u56fe\u7247[12]-\u5403\u4e86\u5403\u4e86\" decoding=\"async\" src=\"https:\/\/cdn.ineuro.net\/cloudreve%2F2024%2F04%2F12%2FfAXbeUX9_1.6.png\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">TREM2\u7f3a\u9677\u95f4\u63a5\u635f\u5bb3DOL\u8bf1\u5bfc<\/h2>\n\n\n\n<p>\u7531\u4e8e\u6211\u4eec\u4e4b\u524d\u7684\u7814\u7a76\u8868\u660e\uff0c\u57285XFAD\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c\u53cd\u5e94\u6027\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u90e8\u5206\u4f9d\u8d56\u4e8eTREM2,30\uff0c\u6211\u4eec\u7814\u7a76\u4e86TREM2\u7f3a\u9677\u5bf9DOL\u8bf1\u5bfc\u7684\u5f71\u54cd\u3002<br>TREM2\u7ef4\u6301\u5c0f\u80f6\u8d28\u7ec6\u80de\u6e05\u9664\u53d7\u635f\u9ad3\u9798\u7684\u80fd\u529b\uff0c\u4ece\u800c\u4f7f\u540e\u7eed\u9ad3\u9798\u518d\u751f\u6210\u4e3a\u53ef\u80fd21,86-88\u3002\u7136\u800c\uff0cTREM2\u662f\u5426\u4ee5\u7ec6\u80de\u5916\u65b9\u5f0f\u95f4\u63a5\u5f71\u54cd\u5176\u4ed6\u7ec6\u80de\u5bf9\u9ad3\u9798\u6539\u53d8\u505a\u51fa\u53cd\u5e94\uff1f 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